Decades of conflict in South Sudan, pre and post-independence in 2011, poverty and poor access to services have increased the rate of disability and rendered people with disabilities more marginalised and excluded as a result of the numerous attitudinal, environmental, and institutional barriers they face, and the lack of concerted efforts to include them. This rapid review identifies the available evidence on the experiences of people with disabilities living in South Sudan. There are still numerous evidence gaps in relation to the experiences of people with disabilities living in South Sudan as very little research has looked at disability in South Sudan and the available evidence base is extremely limited. Much of the available information focuses on Juba rather than the rest of the country. Further research with people with different types of disabilities, and in different areas of South Sudan is needed to more fully understand the experiences of people with disabilities living on South Sudan, the barriers and challenges they face, and how they and their families have responded to them.