This paper examines the political economy of agricultural commercialisation in Ghana from the year 2000 to 2018. Agriculture is a major economic activity in Ghana, contributing about 20 percent to the country’s gross domestic product (GDP) and employing 42 percent of the economically active population (GSS 2016). Over the past three decades, the agricultural sector averagely grew at about 5 percent per annum, making Ghana’s agricultural sector one of the top performers in Africa, and contributing to poverty reduction and food security (Wiggins and Leturque 2011; Sarpong and Anyidoho 2012).The paper is structured into five sections. Section 2 presents the agricultural policy context which highlights features of the agricultural sector, contribution of agriculture to the economy of Ghana and political changes. Section 3 presents theoretical perspectives that will be relied upon for the analysis, while Section 4 discusses the main policies and how they have been shaped by various narratives, actors and interests. Finally, Section 5 presents the main conclusions from the analysis.